PROTEIN RAS-LIKE PROTEINS FROM RAT BRAIN SEBAGAI TARGET PENGHAMBATAN PERKEMBANGAN SEL KANKER

NI MADE WIASTY SUKANTY, I PUTU BAYU AGUS SAPUTRA, FARIDA ARIANI, LINA YUNITA, NOVIANTI TYSMALA DEWI

Abstract


Ras-like proteins from rat brain (Rab) is one of the crucial proteins in the process of intracellular transport. Rab plays a role in delivering vesicles from the donor membrane to the acceptor membrane. Vesicles contain various molecules that are important in cell growth and development. These molecules are generally involved in some signaling pathways. In carrying out its functions, Rab needs to be activated first. The activation process of Rab involves various proteins. Thus, Rab activation and deactivation control are critical to regulating the movement of the transferred molecules. In cancer, there is an uncontrolled activation and deactivation of Rab. Rab's involvement in various signaling pathways by providing molecules needed for growth and development is a basis for increasing the speed of growth and development of cancer cells. Although Rab is not the main factor causing cancer, it can help the development of cancer. So, it can be one of the keys to controlling the transfer of molecules involved in the growth and development of cancer cells. There are several methods related to the activation of Rab for molecular transport. Rab activation inhibition by Rab inhibitors and inhibitors of Rab activating proteins and the use of miRNAs can prevent molecule transport. Thus, control of Rab activation can be an alternative to suppress the growth and development of cancer cells.


Keywords


Ras-like proteins from rat brain (Rab), MicroRNAs, biological transport, signal transduction, neoplasms

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References


Bhuin, T., & Kumar, J. (2014). Rab Proteins : The Key Regulators of Intracellular Vesicle Transport. Experimental Cell Research, 328, 1–19. https://doi.org/10.1016/j.yexcr.2014.07.027

Guadagno, N. A., & Progida, C. (2019). Rab GTPases : Switching to Human Diseases. Cells, 8, 1–25. https://doi.org/10.3390/cells8080909

Huang, H., Jiang, Y., Wang, Y., Chen, T., Yang, L., He, H., … Liu, G. (2015). miR-5100 Promotes Tumor Growth in Lung Cancer by Targeting Rab6. Cancer Letters, 362(1), 15–24. https://doi.org/10.1016/j.canlet.2015.03.004

Katarzyna, M., Ka, A., Kusy, D., Niinivehmas, S. P., & Gmach, J. (2017). Identification of The Privileged Position in The Imidazo [1,2-a] Pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) Inhibitors. Journal of Medicinal Chemistry, 60(21), 8781–8800. https://doi.org/10.1021/acs.jmedchem.7b00811

Khan, F. I., Aamir, M., Wei, D., & Ahmad, F. (2016). Molecular Mechanism of Ras-Related Protein Rab-5A and Effect of Mutations in The Catalytically Active Phosphate-Binding Loop. Journal of Biomolecular Structure and Dynamics, 1102(January), 1–26. https://doi.org/10.1080/07391102.2015.1134346

Kjos, I., Vestre, K., Guadagno, N. A., Borg Distefano, M., & Progida, C. (2018). Rab and Arf proteins at the crossroad between membrane transport and cytoskeleton dynamics. Biochimica et Biophysica Acta - Molecular Cell Research, 1865(10), 1397–1409. https://doi.org/10.1016/j.bbamcr.2018.07.009

Krishnan, P. D. G., Golden, E., Woodward, E. A., Pavlos, N. J., & Blancafort, P. (2020). Rab GTPases : Emerging Oncogenes and Tumor Suppressive Regulators for the Editing of Survival Pathways in Cancer. Cancers, 12(259), 1–19. https://doi.org/10.3390/cancers12020259

Kulakowski, G., Bousquet, H., Patricia, J. M., Goud, B., & Oesterlin, L. K. (2018). Lipid Packing Defects and Membrane Charge Control RAB GTPase Recruitment. Wiley Traffic, (March), 536–545. https://doi.org/10.1111/tra.12568

Langemeyer, L., Perz, A., Kümmel, D., & Ungermann, X. C. (2018). A Guanine Nucleotide Exchange Factor (GEF) Limits Rab GTPase – Driven Membrane Fusion. Journal of Biological Chemistry, 293, 731–739. https://doi.org/10.1074/jbc.M117.812941

Pfeffer, S. R. (2018). LRRK2 and Rab GTPases. Biochemical Society Transactions, 1–6. https://doi.org/10.1042/BST20180470

Porther, N., & Barbieri, M. A. (2015). The Role of Endocytic Rab GTPases in Regulation of Growth Factor Signaling and The Migration and Invasion of Tumor Cells. Small GTPases, 6(3), 135–144. https://doi.org/10.1080/21541248.2015.1050152

Pylypenko, O., Hammich, H., Yu, I., & Houdusse, A. (2018). Rab GTPases and Their Interacting Protein Partners : Structural Insights Into Rab Functional Diversity. Small GTPases, 9, 22–48. https://doi.org/10.1080/21541248.2017.1336191

Qin, X., Wang, J., Wang, X., Liu, F., Jiang, B., & Zhang, Y. (2017). Targeting Rabs As A Novel Therapeutic Strategy For Cancer Therapy. Drug Discovery Today, 22(8), 1139–1147. https://doi.org/10.1016/j.drudis.2017.03.012

Shahabi, A., & Ansarin, K. (2019). The Relationship Between microRNAs and Rab Family GTPases in Human Cancers. Journal of Cellular Physiology, 234(8), 1–12. https://doi.org/10.1002/jcp.28038

Yang, X.-Z., Li, X.-X., Zhang, Y.-J., Rodriguez-Rodriguez, L., Xiang, M.-Q., Wang, H.-Y., & Zheng, X. (2016). Rab1 in Cell Signaling, Cancer and Other Diseases. Oncogene, 35, 1–6. https://doi.org/10.1038/onc.2016.81

Zhen, Y., & Stenmark, H. (2015). Cellular Functions of Rab GTPases at A Glance. Journal of Cell Science, 128, 3171–3176. https://doi.org/10.1242/jcs.166074




DOI: https://doi.org/10.35327/gara.v17i4.661

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